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加热蛋白溶菌酶能杀灭诺如病毒
文章来源:中国医药化工网    添加人:admin    添加时间:2016/12/8 15:45:15
 

   日本东京海洋大学的一个研究小组日前宣布,在实验中发现,加热处理鸡蛋蛋白含有的溶菌酶,能灭活诺如病毒。这是由于溶菌酶能破坏包裹诺如病毒基因的外壳。

    诺如病毒会引发急性肠胃炎和食物中毒。这种病毒具有强大的感染力,只要有10至100个病毒体进入人体,就会导致感染,目前还没有有效的抗病毒剂。

    研究小组利用实验鼠的诺如病毒替代人类诺如病毒进行了实验。他们将蛋白中含有的溶菌酶在100摄氏度下加热40分钟,使其变性。接下来,将含有1%加热处理过的溶菌酶的溶液与实验鼠诺如病毒混合在一起,并观察了1分钟之后的变化。溶菌酶是蛋白等含有的一种能水解致病菌中黏多糖的碱性酶。

    研究人员发现,诺如病毒基因量大幅减少,以致无法检出,并观察到病毒体出现膨胀。他们认为这是由于包裹病毒基因的外壳被破坏导致的。

    研究人员指出,实验鼠诺如病毒和人类诺如病毒从遗传学上来看非常类似,所以这种加热变性处理的蛋白溶菌酶对人类诺如病毒应该也有效果。他们希望将其制成消毒喷雾剂,在下一年度达到实用化。

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